Functional Interrogation of Genes Driving Colorectal Cancer
by young on Feb.07, 2010, under ChemSem 04, _Spring 2010
On February fourth, there was a presentation about colon and rectal cancer given by Amanda B. Hummon, who is from University of Notre Dame. Her presentation title was “Functional Interrogation of Genes Driving Colorectal Cancer.” I thought that her presentation was very well organized. Also, she explained basic information about cancer cell without difficult words, which made me understand her presentation much easier.
She started the seminar introducing basic properties of cancer cell to us. The cancer cell is caused by disease on genome which is particular number and combination of certain chromosomes. She also explained about the basic structure of chromosome which contains gene in it. I learned that the white region of a chromosome is gene rich zone, while the black region of the chromosome is gene poor zone. There are several factors which contribute to occurring cancer cells, which are DNA, RNA, Function, pathways and etc. Dr. Hummon especially focused on the relationship between DNA, RNA and cancer cells.
She collected sample of tumor and mucosa cells from patients to compare them. In the future, she said that she would like to have an experiment how the genes are regulated by mRNA and protein. Throughout the presentation, I wondered how she obtained DNA from tumor cells. I also would like to ask her what causes the change of number or shape of gene or chromosome.
I would tell my friends that the presentation is about the factors which cause cancer in colon or rectum in microscopic views such as DNA, RNA, or protein.
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